Tottenham Hotspur
| Loss |  | Crystal Palace | 0 - 3 | [Match Report] |
| Win |  | Watford | 1 - 0 | [Match Report] |
| Win |  | Wolverhampton Wanderers | 1 - 0 | [Match Report] |
| Win |  | Manchester City | 1 - 0 | [Match Report] |
 | Chelsea | 16:30 Sun 19 Sep (BST) | Home |
 | Arsenal | 16:30 Sun 26 Sep (BST) | Away |
 | Aston Villa | 14:00 Sun 03 Oct (BST) | Home |
 | Newcastle United | 16:30 Sun 17 Oct (BST) | Away |
 | West Ham United | 14:00 Sun 24 Oct (BST) | Away |
| Id | First Name | Surname | Position | Age | Nationality | Squad Number | Club | Last Season | Season Points | Owner | Auction |
|---|
| Player | Position | Matches | ||
| Japhet Tanganga | Defender | 1 | ||
| Player | Position | Description | Expected Return | Next Match |
| Eric Dier | Midfielder | Thigh Injury | 19/09/2021 | 25% |
| Giovani Lo Celso | Midfielder | Other | 19/09/2021 | 50% |
| Cristian Romero | Defender | Other | 19/09/2021 | 50% |
| Davinson Sanchez | Defender | Other | 19/09/2021 | 50% |
| Ryan Sessegnon | Midfielder | Other | 19/09/2021 | 25% |
| Heung-Min Son | Striker | Calf/Shin/Heel Injury | 19/09/2021 | 25% |